Previous Research Accomplishments
Explore the scholarly contributions and landmark studies led by our directors and scientists that have shaped the field and laid the groundwork for our current endeavors.
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1. Nature Biomedical Engineering (2023). “Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate.”
2. Nature Biomedical Engineering (2022). “Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics.”
3. Nature Biomedical Engineering (2021). “Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device.”
4. Nature Biomedical Engineering (2021). “Selective multiplexed enrichment for the detection and quantitation of low-fraction DNA variants via low-depth sequencing.”
5. Nature Biomedical Engineering (2017). “Multiplexed enrichment of rare DNA variants via sequence-selective and temperature-robust amplification.”
6. Nature Methods (2015). "Continuously tunable nucleic acid hybridization probes."
7. Science (2007). "Engineering entropy-driven reactions and networks catalyzed by DNA."
8. Science (2006). "Enzyme-free nucleic acid logic circuits."
9. Cancer Discovery (2018). "A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling."
10. Nature Chemistry (2018). "Predicting DNA hybridization kinetics from sequence."
11. Nature Chemistry (2017). "Modular probes for enriching and detecting complex nucleic acid sequences."
12. Nature Chemistry (2015). "Simulation-guided DNA probe design for consistently ultraspecific hybridization."
13. Nature Chemistry (2013). "Conditionally fluorescent molecular probes for detecting single base changes in double-stranded DNA."
14. Nature Chemistry (2012). "Optimizing the specificity of nucleic acid hybridization."
15. Nature Chemistry (2011). "Dynamic DNA nanotechnology using strand-displacement reactions."
16. Nucleic Acids Research (2020). "High-throughput methods for measuring DNA thermodynamics."
17. Nucleic Acids Research (2020). "Encoding multiple digital DNA signals in a single analog channel."
18. Nucleic Acids Research (2010). "Robustness and modularity properties of a non-covalent DNA catalytic reaction."
19. Nature Communications (2022). "Designing highly multiplex pcr primer sets with simulated annealing design using dimer likelihood estimation (saddle)."
20. Nature Communications (2022). "Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling."
21. Nature Communications (2021). "Calibration-free NGS quantitation of mutations below 0.01% VAF."
22. Nature Communications (2021). "A deep learning model for predicting next-generation sequencing depth from DNA sequence."
23. Nature Communications (2020). "Metastable hybridization-based DNA information storage to allow rapid and permanent erasure."
24. Nature Communications (2018). "Simultaneous and stoichiometric purification of hundreds of oligonucleotides."
25. Nature Communications (2016). "Native characterization of nucleic acid motif thermodynamics via non-covalent catalysis."
26. Nature Communications (2013). "Integrating DNA strand-displacement circuitry with DNA tile self-assembly."
27. Advanced drug delivery reviews (2016). "Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches."
28. ACS nano (2014). "Developmental self-assembly of a DNA tetrahedron."
29. Journal of the American Chemical Society (2011). "Remote toehold: a mechanism for flexible control of DNA hybridization kinetics."
30. Journal of the American Chemical Society (2011). "Cooperative hybridization of oligonucleotides."
31. Journal of the American Chemical Society (2009). "Control of DNA strand displacement kinetics using toehold exchange."
32. Journal of the American Chemical Society (2008). "Dynamic allosteric control of noncovalent DNA catalysis reactions."
33. Science Advances (2022). "Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors."
34. Science Advances (2017). "Sub–100-nm metafluorophores with digitally tunable optical properties self-assembled from DNA."
35. Cancer Research (2020). "Plasma-based BDA-NGS test holds potential in circulating nucleic acid based oncogenic aberration detection."
36. Genome Biology (2021). "Oncogene concatenated enriched amplicon nanopore sequencing for rapid, accurate, and affordable somatic mutation detection."
37. Small (2014). "Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity."
38. ACS Sensors (2022). "Cost-Efficient Sequence-Based Nonextensible Oligonucleotide in Real-Time PCR and High-Throughput Sequencing."
39. ACS Sensors (2020). "Nucleic Acid Quantitation with Log–Linear Response Hybridization Probe Sets."
40. Analytical Chemistry (2022). "Hairpin structure facilitates multiplex high-fidelity DNA amplification in real-time polymerase chain reaction."
41. Analytical Chemistry (2022). "Single-Tube qPCR Detection and Quantitation of Hotspot Mutations Down to 0.01% Variant Allele Fraction."
42. Genetics in Medicine (2020). "Low-level parental somatic mosaic SNVs in exomes from a large cohort of trios with diverse suspected Mendelian conditions."
43. IEEE Transactions on Information Forensics and Security (2012). "An optimized wavelength band selection for heavily pigmented iris recognition."
44. iScience (2022). "Direct capture and sequencing reveal ultra-short single-stranded DNA in biofluids."
45. Scientific Reports (2021). "Confirming putative variants at≤ 5% allele frequency using allele enrichment and Sanger sequencing."
46. Scientific Reports (2021). "High sensitivity Sanger sequencing detection of BRAF mutations in metastatic melanoma FFPE tissue specimens."
47. Journal of the Royal Society Interface (2015). "DyNAMiC Workbench: an integrated development environment for dynamic DNA nanotechnology."
48. American Journal of Medical Genetics Part A (2019). "A recurrent 8 bp frameshifting indel in FOXF1 defines a novel mutation hotspot associated with alveolar capillary dysplasia with misalignment of pulmonary veins."
49. Natural Computing (2009). "Error suppression mechanisms for DNA tile self-assembly and their simulation."
50. Journal of Algorithms (2005). "FFT-based algorithms for the string matching with mismatches problem."
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1. Biomaterials (2000). “Bacterial colonization of functionalized polyurethanes.”
2. Diabetes Care (1988). “Laboratory Evaluation of New Reusable Blood Glucose Sensor.”
3. Journal of the American Academy of Dermatology (2022). “Mechanism for improvement in the appearance of skin laxity resulting from a single treatment with acoustic subcision: Induction of new collagen (type III) and elastin.”
4. International Journal of Modelling and Simulation (2015). “Energy Harvesting Antennas or When is a Monopole Half of a Dipole?”
5. Lasers in Surgery and Medicine (2022). “Long-term improvement in the appearance of hypertrophic scars following a single treatment with acoustic subcision—A single center proof-of-concept study.”
6. Lasers in Surgery and Medicine (2021). “Improvement in the appearance of cellulite and skin laxity resulting from a single treatment with acoustic subcision: Findings from a multicenter pivotal clinical trial.”
7. Lasers in Surgery and Medicine (2019). “Increased Tattoo Fading in a Single Laser Tattoo Removal Session Enabled by a Rapid Acoustic Pulse Device: A Prospective Clinical Trial.”
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1. Biofabrication (2022). “Human gelatin-based composite hydrogels for osteochondral tissue engineering and their adaptation into bioinks for extrusion, inkjet, and digital light processing bioprinting.”
2. Bioprinting (2021). “Three-dimensional printing of click functionalized, peptide patterned scaffolds for osteochondral tissue engineering.”
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1. Cell (2014). "An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation."
2. Biomaterials (2023). "Hydrogel-encapsulation to enhance bacterial diagnosis of colon inflammation."
3. Elife (2019). "An elusive electron shuttle from a facultative anaerobe."
4. ACS Synthetic Biology (2019). "Modifying Cytochrome c Maturation Can Increase the Bioelectronic Performance of Engineered Escherichia coli."
5. Scientific Reports (2018). "PEDOT: PSS-based multilayer bacterial-composite films for bioelectronics."
6. PLoS Pathogens (2009). "Functional Analysis of the Quorum-Sensing Streptococcal Invasion Locus (sil)."
7. PLoS One (2021). "Electronic control of redox reactions inside Escherichia coli using a genetic module."
8. PLoS One (2017). "A portable bioelectronic sensing system (BESSY) for environmental deployment incorporating differential microbial sensing in miniaturized reactors."
9. Frontiers in Cellular and Infection Microbiology (2014). "Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus."
10. Future Microbiology (2014). "Group A streptococcus and host metabolism: virulence influences and potential treatments."
11. Molecular Microbiology (2007). "Transcriptional regulation of the sil locus by the SilCR signalling peptide and its implications on group A streptococcus virulence."